{
  "report_id": "theme_ai_enabled_biology_node_clinical_translation_and_evidence_rails",
  "report_type": "theme_value_chain_node",
  "site_path": "themes/ai-enabled-biology-and-scientific-discovery/nodes/clinical-translation-and-evidence-rails/index.html",
  "title": "Clinical Translation And Evidence Rails",
  "as_of": "2026-06-13",
  "generated_at": "2026-06-13T13:20:00-07:00",
  "freshness": {
    "price_data_as_of": "2026-06-12",
    "daily_ohlc_latest": "2026-06-12",
    "chart_interval": "weekly",
    "knowledge_reviewed_as_of": "2026-06-13",
    "web_research_as_of": "2026-06-13",
    "api_required": true,
    "runtime_price_data": "Resolved by local report API at request time; authoring validation used read-only DuckDB coverage through 2026-06-12.",
    "chartable_names": 7,
    "selected_security_chart_source": "/api/securities/{ticker}/chart?frequency=weekly&window=3y&as_of=latest",
    "short_history_caveat": "TEM has daily_ohlc history from 2024-06-14 through 2026-06-12, so its three-year right-rail chart begins at public trading history.",
    "static_setup_caveat": "Static thresholds in the prior node build were generated from daily_ohlc through 2026-06-05 and must be recalculated before use as current trading evidence."
  },
  "revision": {
    "version": 2,
    "updated_label": "Reformatted node to visual setup, basket cards, evidence board, current earnings-date and revenue sourcing, and right-rail chart provenance",
    "metadata_path": "themes/ai-enabled-biology-and-scientific-discovery/nodes/clinical-translation-and-evidence-rails/report.json",
    "curation_source": "Manual node build; no node-data.json exists for this theme at authoring time."
  },
  "node": {
    "slug": "clinical-translation-and-evidence-rails",
    "order": 6,
    "level": "L3 clinical evidence node",
    "role": "Turns AI-enabled discovery output into trials, regulated data, model credibility, safety evidence, real-world evidence, and submission workflows.",
    "description": "Clinical translation and evidence rails are the contract research organizations, regulated software systems, biosimulation platforms, real-world-data vendors, diagnostics data assets, and safety workflows that turn an AI-generated biology idea into trial evidence a sponsor, physician, payer, or regulator can inspect. Sponsors pay through clinical study contracts, software subscriptions, data licenses, diagnostic testing, and model-informed development work. The current basket read is that IQV and VEEV have the broadest source-backed clinical and workflow exposure; MEDP and ICLR are the main trial-execution checks; CERT and TEM add specialized model-informed and clinical-genomic evidence; CRL is useful but more upstream and currently has weaker organic evidence."
  },
  "ticker_baskets": {
    "core": [
      "IQV",
      "VEEV",
      "MEDP",
      "ICLR",
      "CERT",
      "TEM",
      "CRL"
    ],
    "option": [],
    "watch": []
  },
  "chart_artifacts": [
    {
      "chart_id": "chart-iqv",
      "ticker": "IQV",
      "source_table": "daily_ohlc",
      "chart_interval": "weekly",
      "aggregation": "weekly bars grouped from daily rows by calendar week; open is first row, high is weekly max, low is weekly min, close is final row, volume is summed",
      "indicators": [
        "20w_ema",
        "100w_ema",
        "weekly_volume",
        "20w_average_volume"
      ],
      "indicator_method": "20-week and 100-week exponential moving averages computed from weekly closes using full available weekly history before visible-window clipping; weekly volume bars shown with a 20-week average volume line",
      "price_data_as_of": "2026-06-12",
      "visible_years": 3,
      "rendering": "report_api_selected_security",
      "api_route": "/api/securities/IQV/chart?frequency=weekly&window=3y&as_of=latest"
    },
    {
      "chart_id": "chart-veev",
      "ticker": "VEEV",
      "source_table": "daily_ohlc",
      "chart_interval": "weekly",
      "aggregation": "weekly bars grouped from daily rows by calendar week; open is first row, high is weekly max, low is weekly min, close is final row, volume is summed",
      "indicators": [
        "20w_ema",
        "100w_ema",
        "weekly_volume",
        "20w_average_volume"
      ],
      "indicator_method": "20-week and 100-week exponential moving averages computed from weekly closes using full available weekly history before visible-window clipping; weekly volume bars shown with a 20-week average volume line",
      "price_data_as_of": "2026-06-12",
      "visible_years": 3,
      "rendering": "report_api_selected_security",
      "api_route": "/api/securities/VEEV/chart?frequency=weekly&window=3y&as_of=latest"
    },
    {
      "chart_id": "chart-medp",
      "ticker": "MEDP",
      "source_table": "daily_ohlc",
      "chart_interval": "weekly",
      "aggregation": "weekly bars grouped from daily rows by calendar week; open is first row, high is weekly max, low is weekly min, close is final row, volume is summed",
      "indicators": [
        "20w_ema",
        "100w_ema",
        "weekly_volume",
        "20w_average_volume"
      ],
      "indicator_method": "20-week and 100-week exponential moving averages computed from weekly closes using full available weekly history before visible-window clipping; weekly volume bars shown with a 20-week average volume line",
      "price_data_as_of": "2026-06-12",
      "visible_years": 3,
      "rendering": "report_api_selected_security",
      "api_route": "/api/securities/MEDP/chart?frequency=weekly&window=3y&as_of=latest"
    },
    {
      "chart_id": "chart-iclr",
      "ticker": "ICLR",
      "source_table": "daily_ohlc",
      "chart_interval": "weekly",
      "aggregation": "weekly bars grouped from daily rows by calendar week; open is first row, high is weekly max, low is weekly min, close is final row, volume is summed",
      "indicators": [
        "20w_ema",
        "100w_ema",
        "weekly_volume",
        "20w_average_volume"
      ],
      "indicator_method": "20-week and 100-week exponential moving averages computed from weekly closes using full available weekly history before visible-window clipping; weekly volume bars shown with a 20-week average volume line",
      "price_data_as_of": "2026-06-12",
      "visible_years": 3,
      "rendering": "report_api_selected_security",
      "api_route": "/api/securities/ICLR/chart?frequency=weekly&window=3y&as_of=latest"
    },
    {
      "chart_id": "chart-cert",
      "ticker": "CERT",
      "source_table": "daily_ohlc",
      "chart_interval": "weekly",
      "aggregation": "weekly bars grouped from daily rows by calendar week; open is first row, high is weekly max, low is weekly min, close is final row, volume is summed",
      "indicators": [
        "20w_ema",
        "100w_ema",
        "weekly_volume",
        "20w_average_volume"
      ],
      "indicator_method": "20-week and 100-week exponential moving averages computed from weekly closes using full available weekly history before visible-window clipping; weekly volume bars shown with a 20-week average volume line",
      "price_data_as_of": "2026-06-12",
      "visible_years": 3,
      "rendering": "report_api_selected_security",
      "api_route": "/api/securities/CERT/chart?frequency=weekly&window=3y&as_of=latest"
    },
    {
      "chart_id": "chart-tem",
      "ticker": "TEM",
      "source_table": "daily_ohlc",
      "chart_interval": "weekly",
      "aggregation": "weekly bars grouped from daily rows by calendar week; open is first row, high is weekly max, low is weekly min, close is final row, volume is summed",
      "indicators": [
        "20w_ema",
        "100w_ema",
        "weekly_volume",
        "20w_average_volume"
      ],
      "indicator_method": "20-week and 100-week exponential moving averages computed from available weekly closes; TEM has daily_ohlc history only from 2024-06-14, so its longer EMA context is short-history-sensitive",
      "price_data_as_of": "2026-06-12",
      "visible_years": 3,
      "rendering": "report_api_selected_security",
      "api_route": "/api/securities/TEM/chart?frequency=weekly&window=3y&as_of=latest"
    },
    {
      "chart_id": "chart-crl",
      "ticker": "CRL",
      "source_table": "daily_ohlc",
      "chart_interval": "weekly",
      "aggregation": "weekly bars grouped from daily rows by calendar week; open is first row, high is weekly max, low is weekly min, close is final row, volume is summed",
      "indicators": [
        "20w_ema",
        "100w_ema",
        "weekly_volume",
        "20w_average_volume"
      ],
      "indicator_method": "20-week and 100-week exponential moving averages computed from weekly closes using full available weekly history before visible-window clipping; weekly volume bars shown with a 20-week average volume line",
      "price_data_as_of": "2026-06-12",
      "visible_years": 3,
      "rendering": "report_api_selected_security",
      "api_route": "/api/securities/CRL/chart?frequency=weekly&window=3y&as_of=latest"
    }
  ],
  "links_out": [
    "theme_ai_enabled_biology_and_scientific_discovery"
  ],
  "knowledge_sources": [
    "../../../../../knowledge/wiki/index.md",
    "../../../../../knowledge/wiki/lanes/sector/health-care.md",
    "../../../../../knowledge/wiki/concepts/themes/health-care-policy-reimbursement-dispersion.md",
    "../../../../../knowledge/wiki/concepts/themes/funding-dependency-and-duration-tolerance.md",
    "../../../../../knowledge/wiki/concepts/themes/ai-biology-platform-validation.md",
    "../../../../../knowledge/wiki/lanes/security/iqv.md",
    "../../../../../knowledge/wiki/lanes/security/veev.md",
    "../../../../../knowledge/wiki/lanes/security/medp.md",
    "../../../../../knowledge/wiki/lanes/security/iclr.md",
    "../../../../../knowledge/wiki/lanes/security/cert.md",
    "../../../../../knowledge/wiki/lanes/security/tem.md",
    "../../../../../knowledge/wiki/lanes/security/crl.md"
  ],
  "external_sources": [
    "https://ir.iqvia.com/press-releases/press-release-details/2026/IQVIA-Reports-First-Quarter-2026-Results/default.aspx",
    "https://ir.veeva.com/news/news-details/2026/Veeva-Announces-Fiscal-2027-First-Quarter-Results/default.aspx",
    "https://investor.medpace.com/news-releases/news-release-details/medpace-holdings-inc-reports-first-quarter-2026-results/",
    "https://www.sec.gov/Archives/edgar/data/0001060955/000162828026038487/iclr-20251231.htm",
    "https://iconplc.gcs-web.com/static-files/a3829ab0-27e5-43c6-b650-ceb018312860",
    "https://ir.certara.com/news-releases/news-release-details/certara-reports-first-quarter-2026-financial-results",
    "https://investors.tempus.com/news-releases/news-release-details/tempus-reports-first-quarter-2026-results/",
    "https://ir.criver.com/news-releases/news-release-details/charles-river-laboratories-announces-first-quarter-2026-results/",
    "https://www.marketbeat.com/stocks/NYSE/IQV/earnings/",
    "https://www.marketbeat.com/stocks/NYSE/VEEV/earnings/",
    "https://www.marketbeat.com/stocks/NASDAQ/MEDP/earnings/",
    "https://www.marketbeat.com/stocks/NASDAQ/ICLR/earnings/",
    "https://www.marketbeat.com/stocks/NASDAQ/CERT/earnings/",
    "https://www.marketbeat.com/stocks/NASDAQ/TEM/earnings/",
    "https://www.marketbeat.com/stocks/NYSE/CRL/earnings/",
    "https://companiesmarketcap.com/iqvia/marketcap/",
    "https://companiesmarketcap.com/veeva-systems/marketcap/",
    "https://companiesmarketcap.com/medpace/marketcap/",
    "https://companiesmarketcap.com/icon-plc/marketcap/",
    "https://companiesmarketcap.com/certara/marketcap/",
    "https://companiesmarketcap.com/tempus-ai/marketcap/",
    "https://companiesmarketcap.com/charles-river-laboratories/marketcap/",
    "https://www.fda.gov/regulatory-information/search-fda-guidance-documents/considerations-use-artificial-intelligence-support-regulatory-decision-making-drug-and-biological",
    "https://www.fda.gov/regulatory-information/search-fda-guidance-documents/use-bayesian-methodology-clinical-trials-drug-and-biological-products"
  ],
  "discovery_sources": [
    {
      "kind": "duckdb_readonly_query",
      "label": "Clinical Translation And Evidence Rails weekly OHLC and EMA chart inputs",
      "query_ref": "discovery:duckdb:daily_ohlc_weekly_aggregation_20w_100w_ema:clinical-translation-and-evidence-rails:2026-06-12"
    },
    {
      "kind": "status",
      "label": "Local daily_ohlc coverage checks",
      "query_ref": "discovery:status:IQV|VEEV|MEDP|ICLR|CERT|TEM|CRL"
    },
    {
      "kind": "lineage-status",
      "label": "Local daily_ohlc lineage checks",
      "query_ref": "discovery:lineage-status:daily_ohlc:IQV|VEEV|MEDP|ICLR|CERT|TEM|CRL"
    },
    {
      "kind": "report-api",
      "label": "Selected-security weekly charts",
      "query_ref": "report-api:/api/securities/{ticker}/chart?frequency=weekly&window=3y&as_of=latest"
    }
  ]
}